(E)-N-[(Benzo[b]thiophen-3-yl)methylene]-N'-(2,5-dichlorophenyl)hydrazine.

Tuberculosis is a contagious disease caused by Mycobacterium tuberculosis. After a long period during which this disease seemed to be declining, the last two decades have seen an unexpected return recorded (Raviglione et al., 1995). Isoniazid, pyraziniamide, ethambutol, rifampicin and streptomycin, generally used in combination, are still the current drugs of choice in the therapy of tuberculosis (Lounis et al., 1997). Numerous recent reports in the literature provide evidence of renewed interest as the search for new antitubercular agents continues. A series of novel hydrazones were synthesized and screened for antitubercular activity at the Tuberculosis Antimicrobial Acquisition and Coordinating Facility (TAACF), and the title compound, (I), was found to be very active, with 96% inhibition in the preliminary screen at 6.25 mg mlÿ1.